Fig. 1
From: Epigenetic regulatory mechanism of ADAMTS12 expression in osteoarthritis
STAT1 regulates ADAMTS12 transcription. Tissues of patients with OA and cartilage tissues of controls. (A) HE, PAS, and safranin O-fast green of human cartilage tissues. n = 5 (B) IHC analysis for STAT1 and ADAMTS12 levels in human cartilage tissues. n = 5 (C and D) The binding of STAT1 on ADAMTS12 promoter in human cartilage tissues by ChIP-qPCR and EMSA analyses. n = 5 (E) Luciferase reporter assay for binding of STAT1 on ADAMTS12 promoter in 293T cells. n = 3. *P < 0.05; **, P < 0.01