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Fig. 4 | Molecular Medicine

Fig. 4

From: Prioritized polycystic kidney disease drug targets and repurposing candidates from pre-cystic and cystic mouse Pkd2 model gene expression reversion

Fig. 4

Pre-cystic Signature Reversion Drug Candidates Target Upregulated Genes in Pre-cystic and Cystic Profiles. Volcano plots of differentially expressed genes (LFC > 2.0, p-adjusted < 0.05) with differential expression of candidate drug targets labeled in the (A) P21 cystic, and (B) P28 cystic. C Alluvial plot of the 16 drugs with upregulated drug targets in both cystic data sets connected to their targets that were also found upregulated in the cystic differentially expressed genes (A, B)

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Molecular Medicine

ISSN: 1528-3658