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Fig. 1 | Molecular Medicine

Fig. 1

From: Tanshinone I specifically suppresses NLRP3 inflammasome activation by disrupting the association of NLRP3 and ASC

Fig. 1

Tanshinone I (Tan I) suppressed NLRP3 inflammasome activation in BMDMs. (A) Tan I’s structure. (B) Cell viability of BMDMs treated with Tan I. (C-J) BMDMs were primed with LPS, then incubated with Tan I and stimulated with nigericin or ATP, cleaved caspase-1(p20) and mature IL-1β (p17) in supernatant (Sup.) were assessed by immunoblotting (C, G), caspase-1 activity (D, H), IL-1β secretion (E, I), and LDH release (F, J) in the supernatant were detected. Data are shown as mean ± SEM from triplicates, **P < 0.01, ***P < 0.001, NS: not significant (one-way ANOVA with Dunnett’s post hoc test)

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Molecular Medicine

ISSN: 1528-3658