Fig. 1

DEC2 is overexpressed in the kidney of Fcgr2b^−/− LN mice. A Increased urinary ACR, a marker for proteinuria, was found in Fcgr2b^−/− mice. Knockdown of DEC2 in kidney tissue partly reversed the proteinuria in mice. B PAS staining showed MCs proliferation and capillary hyperplasia in Fcgr2b^−/− mice, and decreased glomerular injury was found in Fcgr2b^−/− mice with DEC2 Knockdown. C IHC staining proved that DEC2 was overexpressed in the kidney of Fcgr2b^−/− LN mice and a high expression of proliferative marker PCNA found in kidney tissue of Fcgr2b^−/− mice. **P < 0.01 vs. control; ^##P < 0.01 vs. Fcgr2b^−/− + Sh-NC