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Fig. 2 | Molecular Medicine

Fig. 2

From: Knockdown of DEC2 expression inhibits the proliferation of mesangial cells through suppressed glycolysis and p38 MAPK/Erk pathway in lupus nephritis

Fig. 2

Knockdown of DEC2 inhibits LN serum-induced MCs proliferation. A, B LN serum induced a higher expressions of DEC2 mRNA and protein in MCs. The MCs transfected with Sh-DEC2 showed significantly decreased levels of DEC2 mRNA and protein although treated with LN serum. C EdU staining indicated that increased proliferation was found after the MCs treated with LN serum, and the cells transfected with Sh-DEC2 reversed this effect. D This result was further confirmed by the expression of PCNA in LN serum-treated MCs with or without transfected with Sh-DEC2. **P < 0.01 vs. control; ##P < 0.01 vs. LN serum + Sh-NC

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Molecular Medicine

ISSN: 1528-3658