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Fig. 3 | Molecular Medicine

Fig. 3

From: Knockdown of DEC2 expression inhibits the proliferation of mesangial cells through suppressed glycolysis and p38 MAPK/Erk pathway in lupus nephritis

Fig. 3

DEC2 is associated with the glucose metabolism in LN serum-treated MCs. A LN serum induced a higher lactate production in MCs, and DEC2 knockdown partly reversed this effect in LN serum-treated MCs. B LN serum treatment increased the glucose consumption in MCs, and DEC2 knockdown partly reversed this effect in LN serum-treated MCs. C LN serum induced a higher ATP production in MCs, and DEC2 knockdown partly reversed this effect in LN serum-treated MCs. D The mitochondrial membrane potential increased rapidly in LN serum-treated MCs than that in controls, and significantly decreased in the LN serum-treated cells transfected with Sh-DEC2. **P < 0.01 vs. control; ##P < 0.01 vs. LN serum + Sh-NC

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Molecular Medicine

ISSN: 1528-3658