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Fig. 5 | Molecular Medicine

Fig. 5

From: Knockdown of DEC2 expression inhibits the proliferation of mesangial cells through suppressed glycolysis and p38 MAPK/Erk pathway in lupus nephritis

Fig. 5

DEC2 is associated with mitochondrial fitness in LN serum treated MCs. A Diagram for the mitochondrial respiration function. B OCR of the MCs was dynamically monitored along with the sequential addition of oligomycin, FCCP and rotenone/antimycin A. Multiple parameters including basal respiration, ATP production-linked respiration, maximal respiration, spare capacity and proton leak can be calculated. C, D No statistical differences were found in basal respiration and ATP production-linked respiration among each group. E, F Increased maximal respiration and spare capacity were found in the LN serum-treated MCs compared with those in controls. Decreased maximal respiration and spare capacity were observed in LN serum-treated MCs transfected with Sh-DEC2, other than Sh-NC. G No statistical difference was found in proton leak-linked respiration among each group. **P < 0.01 vs. control; ##P < 0.01 vs. LN serum + Sh-NC

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Molecular Medicine

ISSN: 1528-3658