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Fig. 6 | Molecular Medicine

Fig. 6

From: Knockdown of DEC2 expression inhibits the proliferation of mesangial cells through suppressed glycolysis and p38 MAPK/Erk pathway in lupus nephritis

Fig. 6

DEC2 activates MCs glycolysis through TLR4 and glucose transporter 1 (GLUT1) regulation. A Western blot results showed that LN serum activated TLR4 signaling, and DEC2 knockdown inhibited the LN serum-induced TLR4 activation in MCs. Overexpression of DEC2 could also activate the TLR4 signaling. B Increased ECAR value was monitored in MCs overexpressed with DEC2 and TLR4 inhibitor CP suppressed the elevation of ECAR value. C, D Overexpression of DEC2 significantly activated the glycolysis and glycolytic capacity in MCs, and TLR4 inhibitor CP effectively suppressed the elevation of ECAR values. E Overexpression of DEC2 increased the expression of GLUT1 in MCs and CP treatment suppressed the elevation of GLUT1 expression. **P < 0.01 vs. control; ##P < 0.01 vs. LN serum + Sh-NC and Lv-DEC2

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Molecular Medicine

ISSN: 1528-3658