Skip to main content
Fig. 7 | Molecular Medicine

Fig. 7

From: Knockdown of DEC2 expression inhibits the proliferation of mesangial cells through suppressed glycolysis and p38 MAPK/Erk pathway in lupus nephritis

Fig. 7

DEC2 regulates MCs proliferation through TLR4 signaling pathway. A, B Cell proliferation assays indicated that DEC2-induced proliferation could only be partly inhibited by glycolysis inhibitor 2-DG, however, it was completely suppressed after TLR4 inhibitor CP treatment. C P38 MAPK, Erk, PI3K/Akt and NF-κB were found activated in MCs with overexpression of DEC2. These pathways were all inhibited after CP treatment. D Use of multiple inhibitors showed that PI3K/AKT pathway was associated with DEC2-induced glycolysis activation, and p38 MAPK, ERK and NF-κB were independent of this process. E, F The cell proliferation assays indicated that suppression of p38 MAPK and ERK signaling can partly inhibited DEC2-induced MCs proliferation, and combined use of p38 MAPK/ERK inhibitors and 2-DG completely inhibited DEC2-induced MCs proliferation. **P < 0.01 vs. control; ##P < 0.01 vs. Lv-DEC2

Back to article page

Molecular Medicine

ISSN: 1528-3658