Table 1 Reactive oxygen and calcium related genes behavior comparison between NNAT overexpression ER + breast cancer cells lines (T47D and ZR75) vs. poor prognosis tumorigenesis in clinical reports. Opposite expression patterns marked in bold
From: NNAT is a novel mediator of oxidative stress that suppresses ER + breast cancer
NNAT overexpression significantly regulated genes | During NNAT overexpression | Expression pattern under tumorigenesis and/or poor prognosis |
|---|---|---|
PML | ↑ | ↓ [61] breast cancer |
MELK | ↓ | ↑ [62] breast cancer |
NOL3 | ↑ | ↓ [63] myeloid malignancies |
APOE | ↑ | ↑ [64] melanoma and glioblastoma exhibited accelerated tumor growth in ApoE-deficient mice |
SOD3 | ↑ | ↓ [65] breast cancer, head and neck cancer, lung cancer, and sarcoma |
PINK1 | ↑ | ↓ [66] breast, colorectal, esophageal, head and neck, liver and ovarian cancers, leukemia and melanoma |
NDUFS8 | ↑ | ↓ [67] Renal cell carcinoma |
NDUFS1 | ↓ | ↑ [68] breast cancer (The Human Protein Atlas data) |
NDUFA3 | ↑ | ↓↑ [68] breast cancer (The Human Protein Atlas data) |
CYP1B1 | ↓ | ↑ [69] breast, brain, colon, ovarian, and prostate cancers |
GPX3 | ↓↑ | ↓ [70] breast cancer |
PDK1 | ↓ | ↑ [71] breast cancer |
DHRS2 | ↓ | ↓ [72] breast cancer |
ANXA1 | ↓ | ↑ [73] breast cancer |
APOD | ↓ | ↑ [74] breast cancer |
NCF2 | ↓ | ↑ [75] kidney Renal Clear Cell Carcinoma |
RAC2 | ↑ | ↓ [68] breast cancer (The Human Protein Atlas data) |
BCL2 | ↓ | ↓ [76] breast cancer |
BCL2L2-PABPN1 | ↑ | |
BBC3 | ↑ | ↓ [79] head and neck cancer |