Table 1 JAB1-interacting proteins

Transcriptional coactivation

c-Jun

Regulating AP-1 transcriptional activity

Claret et al. (1996)

Bcl-3

Facilitating the formation of NF-κB/p50 and DNA complex

Dechend et al. (1999)

HAND2

Augmenting HAND2 transcriptional activity by enhancing HAND2 DNA binding

Dai et al. (2004)

LFA-1

LFA-1 interacts with the transcriptional co-activator JAB1 to modulate AP-1 activity

Bianchi et al. (2000)

Brn-2

Regulating Brn-2 DNA-binding activity

Huang et al. (2005)

5-HT(6)R

5-HT(6)R induced the translocation of Jab1 into the nucleus and increased c-Jun phosphorylation and the interaction between Jab1 and c-Jun

Yun et al. (2010)

Fank1

Suppressing cell apoptosis by activating the AP-1-induced anti-apoptotic pathway

Wang et al. (2011)

MIF

Inhibiting AP-1 activity

Kleemann et al. (2000)

E2F1

Jab1 is an cofactor for E2F1 dependent transcription of apoptotic and mitotic genes

Hallstrom and Nevins (2006), Lu et al. (2011)

DeNEDDylation

Cullins

Modulating the activity of CRLs

Cope et al. (2002), Cope and Deshaies (2003)

MsrA

Enhancing JAB1’s deneddylase activity

Jiang et al. (2020)

Deubiquitination

ANGPTL2

Inhibiting ANGPTL2 degradation

Xie et al. (2021)

PD-L1

Inhibiting PD-L1 degradation

Lim et al. (2016)

EGFR

Inhibiting EGFR degradation

Wan et al. (2019)

Survivin

Inhibiting survivin degradation

Li et al. (2018)

HK2

Inhibiting HK2 degradation

Huang et al. (2020)

FOXM1

Inhibiting FOXM1 degradation

Mao et al. (2019)

ZEB1

Inhibiting ZEB1 degradation

Zhang et al. (2017)

p97/VCP

Controling the ubiquitination status of proteins bound to p97/VCP

Cayli et al. (2009)

ABCA1

Inhibiting ABCA1 degradation

Azuma et al. (2009)

Protein interactions

p53

Promoting p53 nuclear export and degradation

Oh et al. (2006), Zhang et al. (2008)

CENP-T and CENP-W

Promoting the ubiquitin-dependent degradation of CENP-T and CENP-W

Chun et al. (2013)

HIF-1α

Stabilizing HIF-1 alpha aerobically by inhibiting HIF-1 alpha prolyl-hydroxylation

Bemis et al. (2004)

STAMBPL1

Required for the stabilisation and function of STAMBPL1

Chaithongyot and Naumann (2022)

Malt1 and Carma1

Enhancing the stability of Carma1-Bcl10-Malt1 (CBM) complex

Welteke et al. (2009)

p27

Promoting cytoplasmic shuttling and subsequent degradation of p27

Tomoda et al. (2002)

Sec6

Promoting p27 degradation in the cytoplasm via interaction with Jab1

Tanaka and Iino (2014)

Rig-G

Regulating JAB1 cellular distribution through interacting with this protein and increases the intracellular level of p27

Xiao et al. (2006)

PGP9.5 (UCH-L1)

Contributing to p27 degradation via its interaction and nuclear translocation with Jab1

Caballero et al. (2002)

53BP1

Required for mitotic checkpoint activation via its involvement in hyperphosphorylation of 53BP1

Kwak et al. (2005)

RUNX3

Inducing RUNX3 nuclear export and degradation

Kim et al. (2009)

Smad7

Inducing Smad7 nuclear export and degradation

Kim et al. (2004)

TRAF-2

Regulating lysine-63-linked polyubiquitin of TNF receptor-associated-factor 2 which in turn induce TNF-α signaling activation

Wang et al. (2006)

MDM2

Regulating stabilization of MDM2 through inhibiting MDM2 self-ubiquitination

Zhang et al. (2008)

HBx

HBx interacts with Jab1 and trigger AP-1 activation

Tanaka et al. (2006)

LHR precusor

Promoting LHR precusor degradation

Li et al. (2000)

Smad4

Induces its Smad4 ubiquitylation and degradation

Wan et al. (2002)

ERα

Increasing ligand-induced ERα degradation

Callige et al. (2005)

Cyclin E

Promoting Cyclin E degradation

Doronkin et al. (2002)

CDK2

Inhibiting CDK2 phosphorylation via AKT pathway

Yoshida et al. (2013)

Myc

Promoting MYC ubiquitination and degradation

Adler et al. (2006)

MIF

MIF stabilize p27Kip1 by interacting with Jab1; JAB1 inhibits MIF secretion

Kleemann et al. (2000), Lue et al. (2007)

DNA topoisomerase (topo) II α

Promoting topo II α degradation

Yun et al. (2004)

ET(A)R and ET(B)R

Promoting ET(A)R and ET(B)R ubiquitination and degradation

Nishimoto et al. (2010)

Smad5

Inhibiting Smad5-mediated BMP signaling activation

Haag and Aigner (2006)

PR and SRC-1

Stabilizing PR-SRC-1 complexes

Chauchereau et al. (2000)

SMYD3

Jab1-SMYD3 complex activates p16INK4a transcription

Mori et al. (2008)

NCoR

Promoting ubiquitination and proteasome-mediated degradation of NCoR

Lu et al. (2016)

PAR-2

Promoting PAR-2-induced activation of AP-1

Luo et al. (2006)

Rad51

Directly affecting Rad51-p53-binding, stabilizing Rad51 and promoting HR DNA repair

Tian et al. (2010)

CD89

Increasing CD89 surface expression

Bakema et al. (2010)

CPNE1

JAB1 activates the neuronal differentiation through binding to CPNE1

Yoo et al. (2018)

TRAF2

JAB1 regulates ubiquitination of TRAF2

Wang et al. (2006)

Thioredoxin

Stabilizing thioredoxin under oxidative stress

Zhou et al. (2017)

Id3

Mouse Jab1 was identified to interact with Id3 but the effect remains unclear

Bounpheng et al. (2000)

NLRP3

Possibly promoting NLRP3 inflammasome activation

Dai et al. (2020)

Trc8

Trc8 physically interacts with CSN-5 and regulate JAB1 localization

Gemmill et al. (2002)

PDLIM2

PDLIM2 interacts with CSN5 and regulate CSN activity

Bowe et al. (2014)

CSNAP

CSNAP binds CSN3, CSN5, and CSN6, thereby regulates the function of CSN complex

Rozen et al. (2015)