Fig. 4
Energy expenditure in high-fat diet-fed mice with Sirt6 deficiency in microglia. A Images of brown fat and UCP1 immunohistochemical staining. B Serum NE content. n = 7–8/group. C Body core temperature of mice during acute cold exposure. n = 7 /group. D Oxygen consumption of mice exposed to acute cold temperature. n = 5–6/group. E CO2 production of mice exposed to acute cold temperature. n = 5–6/group. F Heat production of mice exposed to acute cold temperature. n = 5–6/group. Data are presented as mean ± SEM, * p < 0.05, ** p < 0.01, *** p < 0.001