Table 2 Univariable and multivariable analyses of associations of TSR and other factors with disease free survival

TSR

 Low

Reference

Reference

Reference

 High

2.12 (1.06–4.23)

2.19 (1.09–4.42)

0.028

2.20 (1.10–4.44)

0.027

BRAF

 Wildtype (wt)

Reference

Reference

 Mutant (mt)

2.70 (1.30–5.61)

2.11 (0.97–4.59)

0.061

NI

KRAS

 Wildtype (wt)

Reference

 Mutant (mt)

1.00 (0.49–2.04)

NI

NI

Microsatellite

 Stable (MSS)

Reference

Reference

 Instable (MSI)

2.53 (1.24–5.17)

NI

1.79 (0.81–3.99)

0.152

Age

1.01 (0.98–1.05)

NI

NI

Gender

 Male

Reference

 Female

1.65 (0.80–3.41)

NI

NI

Comorbidities

 0

Reference

 1

2.34 (0.99–5.53)

  ≥ 2

2.48 (0.79–7.82)

NI

NI

Surgery

 Elective

Reference

 Acute

1.63 (0.48–5.47)

NI

NI

Tumour localisation

 Right colon

Reference

 Left colon

0.92 (0.46–1.81)

NI

NI

TNM stage

 I

Reference

 II

0.71 (0.29–1.72)

NI

NI

Differentiation

 Well/Moderate

Reference

Reference

Reference

 Poor/Undifferentiated

3.28 (1.56–6.90)

2.59 (1.16–5.76)

0.020

2.53 (1.10–5.82)

0.029

Lymph-angio invasion

 No

Reference

 Yes

1.11 (0.46–2.69)

NI

NI