Fig. 6
From: The Rac inhibitor HV-107 as a potential therapeutic for metastatic breast cancer
HV-107 affects Rho GTPases, FAK and Pyk2 signaling in breast cancer cells. Triple negative breast cancer cells MDA-MB-231 (A–H) and MDA-MB-468 (I–P) were exposed to HV-107 at concentrations ranging from 0 to 2000 nM for a duration of 24 h. The western blot images (A, E, I, M) and quantifications for the expression of total and phosphorylated FAK and Pyk2 (B–P) are shown. N = 3. Error bars represent ± SEM; * p ≤ 0.05