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Table 1 Demographic, clinical, and biochemical variables in 56 patients with newly diagnosed and untreated Crohn’s disease

From: High mobility group box 1 and a network of other biomolecules influence fatigue in patients with Crohn’s disease

Variable

 

Age, years

33.5 [16–78]

Male/female

24 (42.9%)/32 (57.1%)

SES-CD

7 [1–37]

HBI (n = 55)

5 [0–14]

Disease distribution

 

 Ileum

29 (51.8%)

 Colon

6 (10.7%)

 Ileocolon

21 (37.5%)

CRP, mg/L

8.5 [1–139]

F-calprotectin, mg/kg (n = 52)

278 [15–4432]

fVAS score

50.5 (25.6)

FSS score

4.0 (1.8)

SF-36vs scorea

61.4 (22.9)

SF-36bp scorea

59 [0–100]

HADS-D (n = 55)

3 [0–13]

IL-1RA, pg/mL

292.2 [126.2–1412.3]

sIL-1RII, ng/mL

6.78 [3.29–49.90]

HSP90α, ng/mL (n = 52)

17.28 [6.44–55.06]

HMGB1, ng/mL (n = 52)

1.17 [0.22–3.33]

Anti-frHMGB1 absb (n = 49)

0.040 [0.040–1.179]

PEDF, ng/mL (n = 46)

655 [458–1100]

HPX, ng/mL (n = 46)

735.3 (224.5)

  1. Values are given as n (%), median [range], or mean (SD)
  2. aSF-36vs- and SF-36bp scores are reported as inverted values, with high numbers indicating low vitality/high bodily pain and low numbers indicating high vitality/low bodily pain. bAbsorbance at 490 nm
  3. abs antibodies, f-calprotectin fecal calprotectin, frHMGB1 fully reduced HMGB1, fVAS fatigue visual analog scale, FSS Fatigue Severity Scale, HADS-D depression subscale of the Hospital Anxiety and Depression Scale, HBI Harvey Bradshaw Index, HMGB1 high mobility group box 1, HPX hemopexin, HSP heat shock protein, IL-1RA interleukin-1 receptor antagonist, sIL-1RII soluble interleukin-1 receptor type 2, PEDF pigment epithelium-derived factor, SES-CD Simple Endoscopic Score for Crohn’s Disease, SF-36 Medical Outcomes Study Short-form Health Survey, SF-36bp the bodily pain subscale of SF-36, SF-36vs the vitality subscale of SF-36
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Molecular Medicine

ISSN: 1528-3658