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Table 2 Associations between fatigue scores and clinical and biochemical variables in 56 patients with Crohn’s disease

From: High mobility group box 1 and a network of other biomolecules influence fatigue in patients with Crohn’s disease

 

Dependent variables

fVAS

FSS

SF-36vsa

B

R2

p-value

B

R2

p-value

B

R2

p-value

Age, years

− 0.37

0.05

0.11

− 0.02

0.02

0.36

− 0.02

0

0.94

SES-CD

0.56

0.03

0.20

0.06

0.06

0.07

1.21

0.17

0.001

HBI (n = 55)

2.04

0.09

0.02

0.19

0.16

0.002

2.31

0.15

0.004

CRP, mg/L

0.20

0.07

0.06

0.01

0.02

0.29

0.25

0.12

0.009

F-calprotectin, mg/kg (n = 52)

0.00

0.02

0.30

0.00

0.07

0.06

0.09

0.09

0.036

SF-36bp scoresa

0.54

0.28

< 0.001

0.04

0.33

< 0.001

0.50

0.29

< 0.001

HADS-D (n = 55)

3.26

0.19

< 0.001

0.29

0.30

< 0.001

3.57

0.29

< 0.001

IL-1RA, pg/mL

0.02

0.03

0.17

0.00

0.01

0.62

0.03

0.14

0.005

sIL-1RII, ng/mL

0.00

0.02

0.37

0.00

0.00

0.91

0.00

0.00

0.77

HSP90α, ng/mL (n = 52)

0.73

0.10

0.03

0.02

0.01

0.45

0.45

0.05

0.13

HMGB1, ng/mL (n = 52)

8.84

0.06

0.08

0.84

0.11

0.02

5.24

0.03

0.24

Anti-frHMGB1 absb (n = 49)

− 41.66

0.20

0.001

− 2.43

0.14

0.01

− 26.02

0.10

0.03

PEDF, ng/mL (n = 46)

0.01

0.00

0.73

− 0.00

0.01

0.55

0.04

0.06

0.12

HPX, ng/mL (n = 46)

0.02

0.02

0.36

0.00

0.04

0.18

0.03

0.11

0.027

  1. Univariable linear regression with fVAS, FSS, and SF-36vs, respectively, as dependent variables. Significant results in bold
  2. aSF-36vs- and SF-36bp scores are reported as inverted values, with high numbers indicating low vitality/high bodily pain and low numbers indicating high vitality/low bodily pain. bAbsorbance at 490 nm
  3. abs antibodies, f-calprotectin fecal calprotectin, frHMGB1 fully reduced HMGB1, fVAS fatigue visual analogue scale, FSS Fatigue Severity Scale, HADS-D depression subscale of the Hospital Anxiety and Depression Scale, HBI Harvey Bradshaw Index, HMGB1 high mobility group box 1, HPX hemopexin, HSP heat shock protein, IL-1RA interleukin-1 receptor antagonist, sIL-1RII soluble interleukin-1 receptor type 2, PEDF pigment epithelium-derived factor, SES-CD Simple Endoscopic Score for Crohn’s Disease, SF-36 Medical Outcomes Study Short-form Health Survey, SF-36bp the bodily pain subscale of SF-36, SF-36vs the vitality subscale of SF-36
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Molecular Medicine

ISSN: 1528-3658