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Table 3 Three multivariable regression models# with fVAS, FSS, and SF-36vs scores respectively as dependent variables

From: High mobility group box 1 and a network of other biomolecules influence fatigue in patients with Crohn’s disease

 

fVAS

 

FSS

 

SF-36vsa

B

p-value

 

B

p-value

 

B

p-value

HADS-D

2.26

0.01

HADS-D

0.23

< 0.001

HADS-D

2.89

< 0.001

SF-36bp scorea

0.48

< 0.001

SF-36bp scorea

0.03

< 0.001

SF-36bp scorea

0.38

< 0.001

HSP90α, ng/mL

0.72

0.01

HMGB1, ng/mL

0.56

0.047

IL-1RA, pg/mL

0.03

0.002

Model summary

R2 = 0.47, p < 0.001

Model summary

R2 = 0.56, p < 0.001

Model summary

R2 = 0.58, p < 0.001

  1. #Forward and backward selection yielded identical results. aSF-36vs- and SF-36bp scores are reported as inverted values, with high numbers indicating low vitality/high bodily pain and low numbers indicating high vitality/low bodily pain. Data are from 56 patients with Crohn’s disease
  2. fVAS fatigue visual analog scale, FSS Fatigue Severity Scale, HADS-D depression subscale of the Hospital Anxiety and Depression Scale, HMGB1 high mobility group box 1, HSP heat shock protein, IL-1RA interleukin-1 receptor antagonist, SF-36 Medical Outcomes Study Short-form Health Survey, SF-36bp the bodily pain subscale of SF-36, SF-36vs the vitality subscale of SF-36