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Fig. 1 | Molecular Medicine

Fig. 1

From: Decreased expression of H19/miR-675 ameliorates muscle atrophy by regulating the IGF1R/Akt/FoxO signaling pathway

Fig. 1

H19/miR-675 was suppressed in mice with HS-induced muscle atrophy. a Changes in mass of the soleus and gastrocnemius muscles after 7 days of HS (n = 6). b, c Real-time PCR analysis of the expression of Atrogin-1 and MuRF1 mRNA in the gastrocnemius and soleus muscles after HS (n = 6). d Western blotting analysis of the expression of Atrogin-1 and MuRF1 protein in the soleus muscles after HS (n = 6). Left panel: representative Western blotting images. Right panel: relative quantitative expression. e, f Real-time PCR analysis of the expression of H19, miR-675-3p, and miR-675-5p RNA in the soleus and gastrocnemius muscles after HS (n = 6). All data are shown as mean ± SD. *P < 0.05 and **P < 0.01 compared to the control group

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Molecular Medicine

ISSN: 1528-3658