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Fig. 3 | Molecular Medicine

Fig. 3

From: HOXA1 participates in VSMC-to-macrophage-like cell transformation via regulation of NF-κB p65 and KLF4: a potential mechanism of atherosclerosis pathogenesis

Fig. 3

Silencing of HOXA1 in the liver attenuates AS-associated lipid metabolic disorder. A Western blot for HOXA1 expression in the liver of wild-type mice with ND, wild-type mice with HFD, or ApoE−/− mice with HFD. B Western blot for HOXA1 expression in the liver of HFD-fed ApoE−/− mice without or with in vivo transduction of AAV1-shNC, AAV1-shHOXA1-1 or AAV1-shHOXA1-2. C Oil red-O staining for the liver of mice in each group. Scale bar = 100 μm (200 ×). D Levels of serum lipids TC, TG, LDL-C, and HDL-C in each group. E Levels of TC, TG, LDL-C, and HDL-C in the liver of each group. Data are expressed as mean ± SD (6 animals/group). Two tailed unpaired t-test was used to calculate the P value in panel A. Ordinary one-way ANOVA followed by Tukey's multiple comparison test was used to calculate the P value in panel B, D, E. *P < 0.05, **P < 0.01, ***P < 0.001, ns: no significance.

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Molecular Medicine

ISSN: 1528-3658