Skip to main content
Fig. 6 | Molecular Medicine

Fig. 6

From: HOXA1 participates in VSMC-to-macrophage-like cell transformation via regulation of NF-κB p65 and KLF4: a potential mechanism of atherosclerosis pathogenesis

Fig. 6

Silencing of HOXA1 inhibits NF-κB p65 and KLF4 expression of AS mice. A EMSA for HOXA1 binding to NF-κB RelA promoter in plaques of mice in each group. B Western blot assay for phospho-p65ser536 and nuclear p65 expression in plaques. C Immunofluorescence double staining for KLF4 (red) and a-SMA (green) in plaques of the aortic root. DAPI (blue) was used for nucleus staining. Scale bar = 50 μm (400 ×). Data are expressed as mean ± SD (6 animals/group). Ordinary one-way ANOVA followed by Tukey's multiple comparison test was used to calculate the P value in panel B. ***P < 0.001

Back to article page

Molecular Medicine

ISSN: 1528-3658