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Fig. 4 | Molecular Medicine

Fig. 4

From: Acetylcholinesterase inhibition protects against trastuzumab-induced cardiotoxicity through reducing multiple programmed cell death pathways

Fig. 4

The effects of donepezil on cardiac injury, oxidative stress, and inflammation in TIC rats. a Cardiac troponin I levels; b NT-proBNP levels; c Serum MDA levels; d Tissue MDA levels; e Il-6 mRNA expression; f Tnf-α mRNA expression; g IL-6 protein expression; h TNF-⍺ protein expression. DPZ donepezil; Il-6 interleukin-6; MDA malondialdehyde; NT-proBNP N-terminal pro B-type natriuretic peptide; Tnf-α tumor necrosis factor-alpha; Trz trastuzumab. n = 6–8 rats per group. Data are presented as the mean ± SEM; *p < 0.05 vs. control; #p < 0.05 vs. Trz

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Molecular Medicine

ISSN: 1528-3658