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Fig. 5 | Molecular Medicine

Fig. 5

From: Acetylcholinesterase inhibition protects against trastuzumab-induced cardiotoxicity through reducing multiple programmed cell death pathways

Fig. 5

The effects of donepezil on cardiac mitochondrial function and dynamics in TIC rats. a Mitochondrial ROS production; b Mitochondrial depolarization; c Mitochondrial swelling; d Mitochondrial morphology; e Mitochondrial OPA1 expression; f Mitochondrial Mfn1 expression; g phosphorylation of Drp1 at serine 616 to total Drp1 ratio; h Mitochondrial Drp1 expression. a.u. arbitrary units; Drp1 dynamin-related protein 1; DPZ donepezil; Mfn1 mitofusin 1; OPA1 optic atrophy 1; Trz trastuzumab; ROS reactive oxygen species; VDAC voltage-dependent anion channel. n = 6–8 rats per group. Data are presented as the mean ± SEM; *p < 0.05 vs. control; #p < 0.05 vs. Trz

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Molecular Medicine

ISSN: 1528-3658