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Fig. 6 | Molecular Medicine

Fig. 6

From: Acetylcholinesterase inhibition protects against trastuzumab-induced cardiotoxicity through reducing multiple programmed cell death pathways

Fig. 6

The effects of donepezil on autophagy and mitophagy in TIC rats. a Beclin-1 expression; b LC3-II expression; c LC3-II/I expression; d p62 expression; e PINK1 expression; f Parkin expression; g phosphorylation of AMPKα at threonine 172 to total AMPKα ratio. AMPKα AMP-activated protein kinase alpha; DPZ donepezil; LC3B-II light chain 3B-II; PINK1 PTEN-induced putative kinase 1; Trz trastuzumab. n = 6–8 rats per group. Data are presented as the mean ± SEM; *p < 0.05 vs. control; #p < 0.05 vs. Trz

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Molecular Medicine

ISSN: 1528-3658