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Fig. 7 | Molecular Medicine

Fig. 7

From: Acetylcholinesterase inhibition protects against trastuzumab-induced cardiotoxicity through reducing multiple programmed cell death pathways

Fig. 7

The effects of donepezil on cardiac apoptosis in rats treated with Trz. a Representative Western blot bands; b Bax/Bcl-2 ratio; c Cytochrome c expression; d Cleaved caspase 3 to pro-caspase 3 ratio; e Representative images of TUNEL-positive cells; white arrow indicated the TUNEL-positive cells. Bax Bcl-2-associated X; Bcl-2 B-cell lymphoma 2; DPZ donepezil; Trz trastuzumab. n = 6–8 rats per group. Data are presented as the mean ± SEM; *p < 0.05 vs. control; #p < 0.05 vs. Trz

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Molecular Medicine

ISSN: 1528-3658