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Fig. 8 | Molecular Medicine

Fig. 8

From: Acetylcholinesterase inhibition protects against trastuzumab-induced cardiotoxicity through reducing multiple programmed cell death pathways

Fig. 8

The effects of donepezil on pyroptosis, ferroptosis, and necroptosis in TIC rats. a NLRP3 expression; b Cleaved Gasdermin D to total Gasdermin D ratio; c ACSL4 expression; d phosphorylation of RIP1 at serine 166 to RIP1 ratio; e phosphorylation of RIP3 at serine 232 to RIP3 ratio; f phosphorylation of MLKL at serine 358 to MLKL ratio. ACSL4 acyl-CoA synthetase long-chain family member 4; DPZ donepezil; MLKL mixed-lineage kinase domain-like; NLRP3 NLR family pyrin domain containing 3 inflammasomes; RIP1 receptor-interacting protein kinase 1; RIP3 receptor-interacting protein kinase 3; Trz trastuzumab. n = 6–8 rats per group. Data are presented as the mean ± SEM; *p < 0.05 vs. control; #p < 0.05 vs. Trz

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Molecular Medicine

ISSN: 1528-3658