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Fig. 9 | Molecular Medicine

Fig. 9

From: Acetylcholinesterase inhibition protects against trastuzumab-induced cardiotoxicity through reducing multiple programmed cell death pathways

Fig. 9

The effects of donepezil on cytotoxicity in cardiomyoblast and breast cancer cells treated with Trz. a Cell viability and b cytotoxicity of H9c2 cells; c Atropine, a muscarinic acetylcholine receptor antagonist was applied in H9c2 cells treated with Trz with or without donepezil 0.5 μM for 48 h; d Cell viability and e cytotoxicity of MCF-7 cells; f Cell viability and g cytotoxicity of MDA-MB-231 cells. ATR atropine; DPZ donepezil; Trz trastuzumab. n = 5 per group. Data are presented as the mean ± SEM; *p < 0.05 vs. control; #p < 0.05 vs. Trz; $p < 0.05 vs. Trz + DPZ

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Molecular Medicine

ISSN: 1528-3658