Tanshinone IIA changed the amniotic fluid volume and regulated expression of AQP1 and AQP3 in amniotic epithelium cells: a promising drug treating abnormal amniotic fluid volume

Table 2 Comparison of atrophied embryos rate, copulation plug rate and successful pregnancy rate between AQP1(−/−) and AQP1(+/+) mice

	AQP1(−/−)		AQP1(+/+)		P
	Control group	Tanshinone IIA group	Control group	Tanshinone IIA group
Atrophied embryos rates n (%)	N^a = 50	N^a = 54	N^a = 74	N^a = 97	0.094
Atrophied embryos rates n (%)	8 (16.0)	10 (18.5)	4 (5.4)	10 (10,3)	0.094
Copulation plug rates n (%)	N^b = 57		N^b = 59		0.000*
Copulation plug rates n (%)	33 (67.9)		55 (93.2)		0.000*
Successful pregnancy rates n (%)	N^b = 33		N^b = 55		0.431
Successful pregnancy rates n (%)	24 (72.7)		44 (80.0)		0.431

^aRefers to the total number of embryos
^bRefers to the total number of mice
*Indicated significant discrepancy in the copulation plug rate between the AQP1 (−/−) and AQP1 (+/+) groups, P < 0.01
Data were compared by Chi-square test, values are reported as n (%)
The number of mice in each of the four groups of atrophied embryos rate was 12

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