Fig. 3

Sexually dimorphic placental pathology after LPS exposure-induced placental inflammation

At GD17.5, placentas (n = 10/group) treated with LPS (400 µg/kg) for 48 h were harvested and stained with hematoxylin and eosin. The female placentas (A) and male placentas (B) were magnified 40x. Scale bar = 200 μm. Black dotted lines divide the trilaminar trophoblast cell layers, and each layer is indicated with black text. Quantitative analysis of the area distribution of (A) is shown as bar graph (C). Quantitative analysis of the area distribution of (B) is shown as bar graph (D). The undrawn with black line and uncut data are shown in Additional file 6: Fig. S5. Differences are represented as the mean ± standard error of mean (SEM). *p < 0.5, **p < 0.01, ***p < 0.001 compared with the PBS group using the Student’s t-test. De, decidua; JZ, junctional zone; La, labyrinth