Fig. 4

Sexually dimorphic transcriptome analysis of placentas after maternal LPS (400 µg/kg) exposure at mid-gestation

(A) Distribution of transcript types that are altered differentially in female and male placentas, respectively. (B) Venn diagram analysis of differentially expressed genes (DEGs) in LPS/PBS group. (C) Hierarchical clustering heatmap and list (right box) of differentially expressed protein-coding genes. (D) Scatter plot analysis of DEGs in LPS/PBS group. The clustered gene families that are decreased only in the female placentas are represented by the yellow color in female LPS/PBS group, and the gene symbol is boxed in both sexes. Enrichment of p-value < 0.05 and fold change > 1.5 was considered for DEGs.