Fig. 2
From: TERC haploid cell reprogramming: a novel therapeutic strategy for aplastic anemia
Relationship between telomerase RNA component (TERC) and pathogenesis of aplastic anemia (AA). The process of cell division differentiation is often accompanied by telomere shortening; this leads to a decrease in hematopoietic stem cells in the bone marrow, which in turn leads to AA. TERC can recruit RNA polymerase to the promoter region of bone marrow genes and regulate myeloid gene expression by recruiting transcription mechanisms; this stimulates a powerful myeloid-promoting response, resulting in an increase in the number of hematopoietic stem cells produced, which could be used to improve the hypohematopoietic function of cells in AA patients