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Fig. 2 | Molecular Medicine

Fig. 2

From: Therapeutic effects of engineered exosome-based miR-25 and miR-181a treatment in spinocerebellar ataxia type 3 mice by silencing ATXN3

Fig. 2

RVG-Lamp2b Exos effectively delivered miRNAs into the brain. (A) In vivo tracking of Cy5-labelled miR-25 in the cerebellum and pons of SCA3 mouse brain 6 h after tail-vein injection of RVG-Lamp2b Exos/miR-25. Scale bar = 50 μm. (B) Comparison of the miR-25 levels in different tissues between control and intravenous RVG-Lamp2b Exos/miR-25 treated group measured by qRT-PCR. (C) Comparison of the miR-181a levels in different tissues between control and intravenous RVG-Lamp2b Exos/miR-181a treated group measured by qRT-PCR. Data were normalized to U6 and presented as fold change relative to the control muscle group. *<0.05

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Molecular Medicine

ISSN: 1528-3658