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Fig. 6 | Molecular Medicine

Fig. 6

From: Therapeutic effects of engineered exosome-based miR-25 and miR-181a treatment in spinocerebellar ataxia type 3 mice by silencing ATXN3

Fig. 6

Effect of exosomal miRNAs on the ATXN3 level. (A-D) Exosomal miR-25 and miR-181a treatment significantly reduced the mutant ATXN3 level in the pons, DCN and cerebellum as evidenced by the quantification of fluorescence intensity 4 weeks after initial injection. Scale bar = 50 μm. (E) Analysis of the cerebellar ATXN3 mRNA level in different groups normalized to GAPDH. (F-G) The cerebellar mutant ATXN3 protein level in different groups as confirmed by Western blotting. *<0.05, **<0.01, ****<0.0001

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Molecular Medicine

ISSN: 1528-3658