Skip to main content
Fig. 3 | Molecular Medicine

Fig. 3

From: HNRNPC promotes collagen fiber alignment and immune evasion in breast cancer via activation of the VIRMA-mediated TFAP2A/DDR1 axis

Fig. 3

Regulation of DDR1 by transcription factor TFAP2A. Note: (A) Correlation analysis of DDR1 and transcription factors MAZ, FOXA1, ZBTB7B, TFAP2A, GATA3, and ZNF263 in breast cancer-related TCGA dataset, including 1096 breast cancer tissues; (B) RT-qPCR detected the expression levels of MAZ, FOXA1, ZBTB7B, TFAP2A, GATA3, and ZNF263 in breast cancer cells (EO771, EMT6, and 4T1.2); (C) RT-qPCR detected the expression levels of TFAP2A in each group of EO771 cells after silencing or overexpression; (D) RT-qPCR detected the expression levels of DDR1 in each group of EO771 cells after silencing or overexpression; (E) Dual-luciferase assay detected the activity of DDR1 promoter in each group of EO771 cells after silencing or overexpression of TFAP2A; (F) ChIP assay detected the enrichment of TFAP2A on DDR1 promoter in each group of EO771 cells after silencing or overexpression of TFAP2A. * indicates P < 0.05, ** indicates P < 0.01 compared with the control group. All cell experiments were repeated 3 times

Back to article page

Molecular Medicine

ISSN: 1528-3658