Fig. 2

Hormones withdrawal disturbed the excitatory/inhibitory ratio of pyramidal neurons from CA1 in the hippocampus. a Schematic diagram of glass microelectrode recorded on subregions of the sagittal hippocampus under the light microscope. The CA1 region was investigated in this research. The white triangle in the left panel marked a pyramidal neuron. b–g Recordings of postsynaptic currents from acute brain slices of the Sham, the HSP, and the HSPP groups. sEPSCs (b–d), sIPSCs (e–g). b, e Representative traces of sEPSCs, and sIPSCs. c, d, f, g Cumulative distribution plots and bar graphs showed the amplitude (left) and frequency (right) of sEPSCs, and sIPSCs. (For all comparisons, n=9 neurons from 3 rats/group). All data were assessed with One-way ANOVA. Turkey’s multiple comparisons test was performed in comparison of the SHAM versus the HSP group, the HSP versus the HSPP group and the SHAM versus the HSPP group. Data represent means ± SEM. *p<0.05, **p<0.005, ***p<0.001