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Fig. 4 | Molecular Medicine

Fig. 4

From: Restoring Wnt signaling in a hormone-simulated postpartum depression model remediated imbalanced neurotransmission and depressive-like behaviors

Fig. 4

Wnt signalling downregulated in the HSPP group. Gene expression profile analysis of the hippocampus of the HSP and HSPP groups. a Differentially expressed genes (DEGs) between the HSP and HSPP groups, with 215 upregulated (red) and 97 downregulated (blue). (Using |log2-fold change|>0.584 (1.5-fold change) and p=0.05 as inclusion criteria). b The KEGG enrichment analysis of the HSP and HSPP groups. The Wnt signalling pathway and several amino acid metabolic pathways associated with depression were enriched. c, d A heatmap and a volcano plot of several key genes involved in Wnt signalling of the HSP and HSPP groups. e Relative expression of β-catenin and sFRP1 (secreted frizzled protein), standardized by the HSP group. These data were assessed with unpaired t-tests. Data represent means ± SEM. *p<0.05, **p<0.005

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Molecular Medicine

ISSN: 1528-3658