Polymorphic variants at NDUFC2, encoding a mitochondrial complex I subunit, associate with cardiac hypertrophy in human hypertension

Table 4 One-way ANOVA adjusted for the following covariates: age, gender, BMI, BP, combination therapy, number of antihypertensive drugs with the NDUFC2/rs641836 polymorphism as independent variable

Variables	GG n = 152	GA n = 85	AA n = 9	NDUFC2 rs641836 p-value; (R²)	Total model p-value; (R²)
Septal thickness (mm)	9.7 ± 1.6 †#	10.4 ± 1.4 *†	12.4 ± 1.8 *#	0.001; (25.0%)	0.002; (17.9%)
LVPW (mm)	9.2 ± 1.5 †#	10.2 ± 1.2 *†	12.0 ± 2.0 *#	0.001; (32.9%)	0.003; (26.5%)
RWT	0.39 ± 0.06 †#	0.42 ± 0.05 *†	0.51 ± 0.09 *#	0.001; (17.5%)	0.036; (9.5%)
LV mass (g)	158.0 ± 42.9 †#	187.0 ± 47.1 *†	229.2 ± 62.7 *#	0.001; (36.2%)	0.004; (30.1%)
LV mass/BSA (g/m²)	85.1 ± 20.1 †#	101.5 ± 23.4 *†	128.0 ± 32.2 *#	0.001; (32.0%)	0.002; (25.4%)
LV mass/h^2.7 (g/m^2.7)	36.5 ± 11.9 †#	42.4 ± 13.8 *†	54.5 ± 9.1 *#	0.003; (22.3%)	0.011; (15.1%)
LA vol/h² (ml/m2)	14.8 ± 3.4 †	15.1 ± 2.2 †	21.9 ± 3.5 *#	0.008; (11.4%)	0.06; (3.8%)

*<0.05 vs. GG; # <0.05 vs. GA; †<0.05 vs. AA
The column titled NDUFC2 rs641836 reports the significance (p-value) and amount of variability (R²) explained by the effect of the Ndufc2 polymorphism independently of all covariates. The column titled Total Model reports the significance (p-value) and amount of variability (R²) explained by the complete analysis. For abbreviations see Table 1

ISSN: 1528-3658