Polymorphic variants at NDUFC2, encoding a mitochondrial complex I subunit, associate with cardiac hypertrophy in human hypertension

Table 5 Echocardiographic variables according to the carrier status of the mutant A allele at NDUFC2/rs641836.

Variables	GG n = 152	GA + AA n = 94	NDUFC2 rs641836 p-value; (R²)	Total model p-value; (R²)
Septal thickness (mm)	9.7 ± 1.6	10.6 ± 1.6	0.001; (17.8%)	0.017; (11.0%)
LVPW (mm)	9.2 ± 1.5	10.4 ± 1.4	0.001; (26.8%)	0.011; (20.8%)
RWT	0.40 ± 0.06	0.43 ± 0.06	0.005; (9.8%)	0.257; (2.3%)
LV mass (g)	158.1 ± 42.9	191.1 ± 49.7	0.001; (32.3%)	0.003; (26.7%)
LV mass/BSA (g/m²)	85.0 ± 21.4	104.0 ± 25.2	0.001; (26.8%)	0.002; (20.7%)
LV mass/h^2.7 (g/m^2.7)	36.7 ± 11.9	43.5 ± 13.8	0.002; (18.7%)	0.010; (12.2%)
LA vol/h² (ml/m²)	14.8 ± 3.4	15.6 ± 2.8	0.062 (6.8%)	0.071 (4.7)

Each row represents a covaried 1-way analysis of variance of 1 individual cardiac parameter, considered as the dependent variable. The column titled NDUFC2 rs641836 reports the significance (p-value) and amount of variability (R²) explained by the effect of the carrier status of the mutant A allele of NDUFC2 rs641836 independently of all covariates (age, gender, BMI, BP, combination therapy, number of antihypertensive drugs). The column titled Total Model reports the significance (p-value) and amount of variability (R²) explained by the complete analysis

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