Polymorphic variants at NDUFC2, encoding a mitochondrial complex I subunit, associate with cardiac hypertrophy in human hypertension

Table 6 One-way ANOVA adjusted for the following covariates: age, gender, BMI, BP, combination therapy, number of antihypertensive drugs with the NDUFC2/rs11237379 polymorphism as independent variable

Variables	CC N = 40	CT N = 131	TT N = 75	NDUFC2 rs11237379 p-value; (R²)	Total model p-value; (R²)
Septal thickness (mm)	9.7 ± 1.5 †	10.0 ± 1.7	10.7 ± 1.6 *	0.001; (21.4%)	0.007; (13.9%)
LVPW (mm)	9.3 ± 1.4 †	9.5 ± 1.5	10.4 ± 1.6 *	0.003; (21.5%)	0.008; (14.0%)
RWT	0.39 ± 0.05 †	0.41 ± 0.06	0.44 ± 0.07 *	0.01; (19.0%)	0.021; (11.2%)
LV mass (g)	164.4 ± 48.4	165.0 ± 49.3	183.0 ± 45.4	0.065; (5.8%)	0.074; (5.1%)
LV mass/BSA (g/m²)	87.5 ± 25.1 †	88.1 ± 23.3 †	101.1 ± 24.7 *#	0.012; (21.0%)	0.03; (13.4%)
LV mass/h^2.7 (g/m^2.7)	36.7 ± 12.2 †	40.0 ± 12.3	42.9 ± 14.1 *	0.033 (15.9%)	0.054 (7.9%)
LA vol/h² (ml/m²)	13.8 ± 1.8	14.7 ± 3.2	16.3 ± 3.7	0.078 (2.3%)	0.081 (1.7%)

*<0.05 vs. CC; # <0.05 vs. CT; †<0.05 vs. TT
The column titled NDUFC2 rs11237379 reports the significance (p-value) and amount of variability (R²) explained by the effect of the NDUFC2 polymorphism independently of all covariates. The column titled Total Model reports the significance (p-value) and amount of variability (R²) explained by the complete analysis. For abbreviations see Table 1

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