Polymorphic variants at NDUFC2, encoding a mitochondrial complex I subunit, associate with cardiac hypertrophy in human hypertension

Table 7 Echocardiographic variables according to the combination of NDUFC2/rs641836 and NDUFC2/rs1123737 genotypes

Variables	A rs641836 allele and TT/ rs11237379 genotype (n = 43)	GG/rs641836 and CC/rs11237379 genotype (n = 40)	NDUFC2 rs641836/ rs1123737 genotype p-value; (R²)	Total model p-value; (R²)
Septal thickness (mm)	11.1 ± 1.7	9.7 ± 1.5	0.001; (23.1%)	0.016; (14.3%)
LVPW (mm)	10.8 ± 1.6	9.3 ± 1.4	0.001; (29.7%)	0.031; (22.5%)
RWT	0.46 ± 0.07	0.39 ± 0.05	0.004; (25.1%)	0.008; (16.9%)
LV mass (g)	191.5 ± 49.4	164.4 ± 48.4	0.002; (24.2%)	0.01; (16.3%)
LV mass/BSA (g/m²)	105.6 ± 27.1	87.5 ± 25.1	0.001; (24.5%)	0.009; (16.4%)
LV mass/h^2.7 (g/m^2.7)	44.3 ± 14.5	36.7 ± 12.2	0.003; (21.2%)	0.027; (12.6%)
LA vol/h² (ml/m²)	16.5 ± 3.8	13.8 ± 1.8	0.176; (2.8%)	0.231 (1.7%)

Due to the small number of subjects carrying homozygosity for the A allele at NDUFC2 rs641836, all individuals carrying the A allele were combined. The column titled NDUFC2 rs641836/ rs1123737 genotype reports the significance (p-value) and amount of variability (R²) explained by the effect of the combination of different genotypes at NDUFC2 rs641836 and rs1123737 independently of all covariates. The column titled Total Model reports the significance (p-value) and amount of variability (R²) explained by the complete analysis. For abbreviations see Table 1

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