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Fig. 8 | Molecular Medicine

Fig. 8

From: Leptin/obR signaling exacerbates obesity-related neutrophilic airway inflammation through inflammatory M1 macrophages

Fig. 8

Leptin concentration and M1 macrophage polarization in obese and nonobese patients with asthma. a The level of leptin in the serum of OA patients (n = 14) and NOA patients (n = 25). b Representative macrophage gating strategy for the induced sputum of OA and NOA subjects. c Bar graph showing the number of M1 macrophages (CD11c+CD86+) in the induced sputum of OA and NOA subjects. d Bar graph showing the number of M2 macrophages (CD68+CD163+) in the induced sputum of OA and NOA subjects. e Correlation between serum leptin and M1 macrophage levels in induced sputum. The data are expressed as the means ± SDs. *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001

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Molecular Medicine

ISSN: 1528-3658