Leptin/obR signaling exacerbates obesity-related neutrophilic airway inflammation through inflammatory M1 macrophages

Table 1 Clinical characteristics of the subjects

	NOA	OA	P value
No. of patients (n)	25	14
Age (y)	49 ± 10.5	54.43 ± 10.77	0.133
Female sex (%)	64	64.3	0.224
BMI	21.43 ± 1.71	30.35 ± 1.83	< 0.0001
Atopy (%)	36	28.58	0.289
FEV₁ (%)	80.84 ± 20.7	73.76 ± 18.7	0.299
FEV₁/FVC	81.72 ± 15.92	79.77 ± 15.58	0.715
Smoking history (never/smoker), no. (%)	76/24	71.4/28.6	0.522
ACT	16.92 ± 3.89	18.14 ± 4.66	0.386
Sputum Neu (%)	29.27 ± 20.91	56.55 ± 28.58	0.0048
Sputum Eso (%)	16.20 [5.97, 31.35]	16.4 ± 14.29	0.418
Peripheral blood
WBC (× 10^9/L)	6.16 ± 1.51	6.48 ± 2.34	0.603
Neutrophils (%)	48.87 ± 16.25	50.49 ± 14.31	0.759
Eosinophils (%)	4.5 ± 4.78	3.79 ± 2.57	0.607

Categorical variables are represented as n (%), and continuous variables following a normal distribution are represented as the mean ± SD, and continuous variables with non-normal distribution are represented as median and quartile. NOA: nonobese asthma; OA: obese asthma; BMI: body mass index; FEV₁: forced exhaled volume at 1 s; FVC: forced vital capacity; ACT: asthma control test; Neu: neutrophils; Eos: eosinophils

ISSN: 1528-3658