Fig. 1
Effect of CLP on the abundance of IR (Insulin Receptor) β and IRS (IR Substrate)-1 in Skeletal Muscle and IRβ and IRS-2 in liver. T: time; subscript indicates time (hrs) post-CLP. Each point represents a measurement in a single animal, heavy bars − mean, light bars − ± standard deviation. Measurements performed using ELISA. Significance determined using one-way ANOVA with Tukey’s post-hoc correction. *Statistically significant relative to concentration at T0, A Effect of CLP on total IRβ abundance in skeletal muscle. N = 2–3 at each time point. B Effect of CLP on total IRβ abundance in Liver. N = 3–4 at each time point. C Effect of CLP on total IRS-1/IRS-2 abundance in Skeletal Muscle. N = 2–4 at each time point. ^Statistically significant relative to concentration of IRS-1 at the same time point. D Effect of CLP on total IRS-2/IRS-1 abundance in Liver. N = 4–5 at each time point. ^Statistically significant relative to concentration of IRS-2 at the same time point