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Fig. 1 | Molecular Medicine

Fig. 1

From: Unveiling the dark side of glucose-regulated protein 78 (GRP78) in cancers and other human pathology: a systematic review

Fig. 1

Illustration of the inactive state of GRP78 and the presence of stress response elements (ERES) positioned upstream of the TATA element. In cells that are not experiencing stress, the ERES region is bound by NFY, SP1, and HDAC1, leading to the maintenance of low transcription levels for GRP78. Additionally, GRP78, located within the lumen of the endoplasmic reticulum (ER), interacts with the ER stress sensors (IRE1, ATF6, and PERK) and acts as a signaling component for the unfolded protein response (UPR)

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Molecular Medicine

ISSN: 1528-3658