Fig. 3From: Unveiling the dark side of glucose-regulated protein 78 (GRP78) in cancers and other human pathology: a systematic reviewA proposed comprehensive pathway illustrating the involvement of GRP78 as a central regulator in the cellular response to endoplasmic reticulum (ER) stress, known as the unfolded protein response (UPR). In this pathway, GRP78 acts as a master regulator, coordinating the UPR signaling cascadeBack to article page