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Fig. 3 | Molecular Medicine

Fig. 3

From: Elevated galectin-3 levels detected in women with hyperglycemia during early and mid-pregnancy antagonizes high glucose − induced trophoblast cells apoptosis via galectin-3/foxc1 pathway

Fig. 3

The regulation of foxc1 expression by galectin-3 in human HTR-8/SVneo cells. (A) PPI network of galectin-3 (LGALS3) and foxc1 was constructed by GeneMANIA.The interconnections between galectin-3 (LGALS3) and foxc1 were explored in term of physical interactions, co-expression, co-localization, genetic interactions, shared protein domains and pathways. (B) Recombinant human galectin-3 up-regulated the mRNA expression level of foxc1. (C) The relative mRNA expression levels of galectin-3 (left panel) and foxc1 (right panel) in HTR-8/SVneo cells transfected with galectin-3 siRNA. (D) Western blotting analysis and quantification of the expression of foxc1 protein level in HTR-8/SVneo cells treated with galectin-3 siRNA and different glucose concentration (5 mM, 11 mM, and 25 mM). *: P < 0.05, **: P < 0.01, and ***: P < 0.001

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Molecular Medicine

ISSN: 1528-3658