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Fig. 1 | Molecular Medicine

Fig. 1

From: AQP3-mediated activation of the AMPK/SIRT1 signaling pathway curtails gallstone formation in mice by inhibiting inflammatory injury of gallbladder mucosal epithelial cells

Fig. 1

High-throughput sequencing and AQP3 expression analysis of gallbladder tissues from cholelithiasis and normal control mice. A, Image of gallbladder stones in cholelithiasis mice; B, Gallbladder stone score; C, Heatmap and volcano plot of differentially expressed genes in gallbladder tissues of normal control and cholelithiasis mice detected by high-throughput sequencing. Green indicates downregulation, red indicates upregulation; D, Bar chart of hub genes in the differentially expressed gene PPI network between normal control and cholelithiasis mice identified by high-throughput sequencing; E, PPI protein interaction network of the hub gene AQP3 in gallbladder tissues of normal control and cholelithiasis mice identified by high-throughput sequencing. Green indicates downregulation, red indicates upregulation; F, RT-qPCR analysis of AQP3 mRNA expression in gallbladder tissues of normal control and cholelithiasis mice; G, Western blot analysis of AQP3 protein expression in gallbladder tissues of normal control and cholelithiasis mice. *p < 0.05, vs. normal control

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Molecular Medicine

ISSN: 1528-3658