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Fig. 8 | Molecular Medicine

Fig. 8

From: AQP3-mediated activation of the AMPK/SIRT1 signaling pathway curtails gallstone formation in mice by inhibiting inflammatory injury of gallbladder mucosal epithelial cells

Fig. 8

Molecular mechanism of AQP3 in cholelithiasis via activation of AMPK/SIRT1 signaling pathway. AQP3 induces the activation of the AMPK/SIRT1 signaling pathway, which can reduce the inflammatory injury of gallbladder mucosal epithelial cells and improve the water transport inside and outside the mucosa. By this mechanism, the gallbladder damage of cholelithiasis can be reduced

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Molecular Medicine

ISSN: 1528-3658