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Fig. 10 | Molecular Medicine

Fig. 10

From: BAP1 mutations inhibit the NF-κB signaling pathway to induce an immunosuppressive microenvironment in uveal melanoma

Fig. 10

Schematic illustration of the molecular mechanism of BAP1 mutations affecting the tumor immune microenvironment in UM. BAP1 mutations may repress the NF-κB signaling pathway, repressing the cytokine secretion and antigen-presenting abilities of macrophages, which induces the immunosuppressive microenvironment, augments the malignant phenotypes of UM cells and ultimately promotes the growth and metastasis of UM.

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Molecular Medicine

ISSN: 1528-3658