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Fig. 1 | Molecular Medicine

Fig. 1

From: RILP inhibits tumor progression in osteosarcoma via Grb10-mediated inhibition of the PI3K/AKT/mTOR pathway

Fig. 1

RILP is downregulated in osteosarcoma and its lower level correlates with poor prognosis in osteosarcoma patients. A Expression profile of RILP in various tumors based on TIMER database. B The relative mRNA level of RILP in tumor and adjacent tissues based on clinical samples. C The protein expression level of RILP in tumor and adjacent tissues on clinical samples was detected by western blotting. GAPDH was used as a loading control. D Quantitative analysis of the protein expression level of RILP. E The protein expression level of RILP in human osteoblasts (hFOB1.19) and osteosarcoma cell lines (HOS, MG63, U2OS and 143B) were subjected to western blotting analysis. GAPDH was used as a loading control. F The relative mRNA level of RILP in human osteoblasts (hFOB1.19) and osteosarcoma cell lines (HOS, MG63, U2OS and 143B). G–I Kaplan–Meier survival analysis of osteosarcoma patients with high and low expression of RILP in TCGA and GEO database. *P < 0.05, **P < 0.01, ***P < 0.001

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Molecular Medicine

ISSN: 1528-3658