Fig. 8From: Acid sphingomyelinase mediates ferroptosis induced by high glucose via autophagic degradation of GPX4 in type 2 diabetic osteoporosisEstablishment of the T2DOP rat model. A FBG and FINS increased and ISI decreased in T2DOP rats. ISI= − ln(FBG × FINS). B Micro-CT analysis of the distal metaphyseal femur region. C Micro-CT-based quantification of BMD, Tb.N, Tb.Th and BV/TV. N = 15, ****P < 0.0001Back to article page